Article

Asparagine endopeptidase cleaves tau at N167 after uptake into microglia

2019-02-26

Abstract excerpt

<h4>Background</h4> Tau cleavage by different proteolytic enzymes generates short, aggregation-prone fragments that have been implicated in the pathogenesis of Alzheimer’s disease (AD). Asparagine endopeptidase (AEP) activity in particular has been associated with tau dysfunction and aggregation, and the activity of the protease is increased in both aging and AD. <h4>Methods and Results</h4> Using a mass spectro...

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Literature Corpus work: 50097d3b-6db0-5b0d-a862-83b6ce28576f
DOI: 10.1101/560110

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