Article

HtrA1 prevents and reverses α-synuclein aggregation, rendering it non-toxic and seeding incompetent

2023-08-22

Abstract excerpt

<title>Abstract</title> <p>Parkinson disease (PD) is closely linked to the misfolding and accumulation of α-synuclein (α-syn) into Lewy bodies. HtrA1 is a PDZ serine protease that degrades fibrillar tau, which is associated with Alzheimer disease (AD). Further, inactivating mutations to mitochondrial HtrA2 have been implicated in PD. Here, we establish that HtrA1 inhibits the aggregation of α-syn as well as FUS a...

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Literature Corpus work: 136336f8-81b2-53f1-a0ce-68436c6ca9d8
DOI: 10.21203/rs.3.rs-2570571/v1

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