Article
Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations.
Proceedings of the National Academy of Sciences of the United States of America - 8 Feb 2005
Li Wenxue, West Neva, Colla Emanuela, Pletnikova Olga, Troncoso Juan C, Marsh Laura, Dawson Ted M, Jäkälä Pekka, Hartmann Tobias, Price Donald L, Lee Michael K
Abstract excerpt
Abnormal biology of alpha-synuclein (alpha-Syn) is directly implicated in the pathogenesis of Parkinson's disease and other alpha-synucleinopathies. Herein, we demonstrate that C-terminally truncated alpha-Syn (alpha-SynDeltaC), enriched in the pathological alpha-Syn aggregates, is normally generated from full-length alpha-Syn independent of alpha-Syn aggregation in brains and in cultured cells. The accumulation...
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