Article

A developmentally programmed splicing failure attenuates the DNA damage response during mammalian zygotic genome activation

2020-11-25

Abstract excerpt

<h4>ABSTRACT</h4> The transition from maternal to embryonic transcriptional control is a crucial step in embryogenesis. However, how alternative splicing is regulated during this process and how it contributes to early development is unknown. Using transcriptomic data from pre-implantation stages of human, mouse and cow, we show that the stage of zygotic genome activation (ZGA) exhibits the highest levels of exon...

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Literature Corpus work: 20b7fdf0-639c-5e9a-8ba6-d8adf54e34e4
DOI: 10.1101/2020.11.25.397794

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