Article

Herpesviruses mimic zygotic genome activation to promote viral replication

2023-12-13

Abstract excerpt

<title>Abstract</title> <p>DUX4 is a germline transcription factor and a master regulator of zygotic genome activation. During early embryogenesis, DUX4 is crucial for maternal to zygotic transition at the 2-8-cell stage in order to overcome silencing of genes and enable transcription from the zygotic genome. In adult somatic cells, DUX4 expression is silenced and its activation in adult muscle cells causes the g...

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Literature Corpus work: 4d542a7d-0041-5067-b89f-abcf025c5ef7
DOI: 10.21203/rs.3.rs-3125635/v1

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