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Herpesviruses mimic zygotic genome activation to promote viral replication

15 Jan 2025

Abstract excerpt

Zygotic genome activation (ZGA) is crucial for maternal to zygotic transition at the 2-8-cell stage in order to overcome silencing of genes and enable transcription from the zygotic genome. In humans, ZGA is induced by DUX4, a pioneer factor that drives expression of downstream germline-specific genes and retroelements. Here we show that herpesviruses from all subfamilies, papillomaviruses and Merkel cell...

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PMID: 39814710
DOI: 10.1038/s41467-025-55928-5

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