Article

Herpesviral induction of germline transcription factor DUX4 is critical for viral gene expression

2021-03-24

Abstract excerpt

DUX4 is a transcription factor and a master regulator of embryonic genome activation (EGA). During early embryogenesis, EGA is crucial for maternal to zygotic transition at the 8-cell stage in order to overcome silencing of genes and enable transcription from the zygotic genome. In adult somatic cells, DUX4 expression is largely silenced. Activation is likely pathogenic, and in adult muscle cells causes genetic di...

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Literature Corpus work: cf3cd0fa-ea9e-5acf-a20e-00a706467ba4
DOI: 10.1101/2021.03.24.436599

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