Article

Transcription activation of early human development suggests DUX4 as an embryonic regulator

2017-04-02

Abstract excerpt

In order to better understand human preimplantation development we applied massively parallel RNA sequencing on 337 single cells from oocytes up to 8-cell embryo blastomeres. Surprisingly, already before zygote pronuclear fusion we observed drastic changes in the transcriptome compared to the unfertilized egg: 1,804 gene transcripts and 32 repeat elements become more abundant, among these the double-homeobox gene...

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Literature Corpus work: 41cee9c3-70a0-50c0-844b-eac5bc9e90b0
DOI: 10.1101/123208

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