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Article

HTLV-1-Derived Exosomes Drive Transcriptional Reprogramming of Monocytes Toward a Mixed M1/M2 Phenotype in HAM/TSP.

Pathogens (Basel, Switzerland) - 3 Jul 2026

MacNary Catherine A, Rajendra Gaekwar Sai Chaitanya, Lemenze Alexander, Naik Ayaan, Tandon Ritesh, Ahmed Salwa, Herrera Bobby Brooke, Jain Pooja

Abstract excerpt

Human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic neuroinflammatory disorder often leading to demyelination of the spinal cord. Progression to HAM/TSP is closely associated with the high proviral load and the presence of virally infected CD4+ T cells that release extracellular vesicles (EVs). Exosomes, an EV subtype released by many cell types,...

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Identifiers

PMID: 42515031
DOI: 10.3390/pathogens15070704
PMCID: PMC13414601

Genes

CD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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