Article

BRD8 guards the pluripotent state by sensing and maintaining histone acetylation

2024-03-20

Abstract excerpt

Epigenetic control of cell fates is a critical determinant to maintain cell type stability and permissive differentiation. However, the epigenetic control mechanisms are not well understood. Here, we show that the histone acetyltransferase reader protein BRD8 impairs the conversion of primed mouse EpiSCs (epiblast stem cells) to naive mouse ESCs (embryonic stem cells). BRD8 works by maintaining histone acetylation...

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Literature Corpus work: dd970299-ba37-5a14-998b-c6c12838e5ec
DOI: 10.1101/2024.03.20.585857

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