Article

Direct detection of the myosin super-relaxed state and interacting heads motif in solution

2021-06-30

Abstract excerpt

We have used time-resolved fluorescence resonance energy transfer (TR-FRET) to detect the interacting-heads motif (IHM) of β-cardiac myosin in solution. Evidence for the IHM has been observed by several structural techniques, and it has been proposed to be the structural basis for the super-relaxed state (SRX), a low-ATPase state of myosin that has been observed biochemically in skinned muscle fibers using fluores...

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Literature Corpus work: dd7e261c-d516-50a2-b82a-3c532439d7f3
DOI: 10.1101/2021.06.29.450383

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