Article
Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers.
Proceedings of the National Academy of Sciences of the United States of America - 28 Aug 2018
Anderson Robert L, Trivedi Darshan V, Sarkar Saswata S, Henze Marcus, Ma Weikang, Gong Henry, Rogers Christopher S, Gorham Joshua M, Wong Fiona L, Morck Makenna M, Seidman Jonathan G, Ruppel Kathleen M, Irving Thomas C, Cooke Roger, Green Eric M, Spudich James A
Abstract excerpt
Mutations in β-cardiac myosin, the predominant motor protein for human heart contraction, can alter power output and cause cardiomyopathy. However, measurements of the intrinsic force, velocity, and ATPase activity of myosin have not provided a consistent mechanism to link mutations to muscle pathology. An alternative model posits that mutations in myosin affect the stability of a sequestered, super relaxed state...
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