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Article

Tail length and E525K dilated cardiomyopathy mutant alter human β-cardiac myosin super-relaxed state.

The Journal of general physiology - 3 Jun 2024

Duno-Miranda Sebastian, Nelson Shane R, Rasicci David V, Bodt Skylar M L, Cirilo Joseph A, Vang Duha, Sivaramakrishnan Sivaraj, Yengo Christopher M, Warshaw David M

Abstract excerpt

Dilated cardiomyopathy (DCM) is a condition characterized by impaired cardiac function, due to myocardial hypo-contractility, and is associated with point mutations in β-cardiac myosin, the molecular motor that powers cardiac contraction. Myocardial function can be modulated through sequestration of myosin motors into an auto-inhibited "super-relaxed" state (SRX), which may be further stabilized by a structural...

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Identifiers

PMID: 38709176
DOI: 10.1085/jgp.202313522
PMCID: PMC11074782

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