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Article

Dilated cardiomyopathy mutation E525K in human beta-cardiac myosin stabilizes the interacting-heads motif and super-relaxed state of myosin.

eLife - 24 Nov 2022

Rasicci David V, Tiwari Prince, Bodt Skylar M L, Desetty Rohini, Sadler Fredrik R, Sivaramakrishnan Sivaraj, Craig Roger, Yengo Christopher M

Abstract excerpt

The auto-inhibited, super-relaxed (SRX) state of cardiac myosin is thought to be crucial for regulating contraction, relaxation, and energy conservation in the heart. We used single ATP turnover experiments to demonstrate that a dilated cardiomyopathy (DCM) mutation (E525K) in human beta-cardiac myosin increases the fraction of myosin heads in the SRX state (with slow ATP turnover), especially in physiological...

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Identifiers

PMID: 36422472
DOI: 10.7554/eLife.77415
PMCID: PMC9691020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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