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Article

Dynamics of β-cardiac myosin between the super-relaxed and disordered-relaxed states.

The Journal of biological chemistry - 1 May 2025

Cail Robert C, Báez-Cruz Faviolla A, Winkelmann Donald A, Goldman Yale E, Ostap E Michael

Abstract excerpt

The super-relaxed (SRX) state of myosin ATPase activity is critical for striated muscle function, and its dysregulation is linked to cardiomyopathies. It is unclear whether the SRX state exchanges readily with the disordered-relaxed (DRX) state and whether the SRX state directly corresponds to the folded back interacting-heads motif. Using recombinant β-cardiac heavy meromyosin and subfragment 1, which cannot...

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Identifiers

PMID: 40118457
DOI: 10.1016/j.jbc.2025.108412
PMCID: PMC12023885

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