Article

AMLs harboring DNMT3A-destabilizing variants show increased intratumor DNA methylation heterogeneity at bivalent chromatin domains

2023-02-14

Abstract excerpt

<h4>ABSTRACT</h4> The mechanistic link between the complex mutational landscape of de novo methyltransferase DNMT3A and the pathology of acute myeloid leukemia (AML) has not been clearly elucidated so far. A recent discovery on the catalogue of DNMT3A-destabilizing mutations throughout the DNMT3A gene as well as the oligomerization-dependent catalytic property of DNMT3A prompted us to investigate the common ef...

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Literature Corpus work: dd5f2db0-61cb-5373-b8d4-fc483930b074
DOI: 10.1101/2023.02.13.528223

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