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Increased local DNA methylation disorder in AMLs with DNMT3A-destabilizing variants and its clinical implication

10 Jan 2025

Abstract excerpt

The mechanistic link between the complex mutational landscape of de novo methyltransferase DNMT3A and the pathology of acute myeloid leukemia (AML) has not been clearly elucidated so far. Motivated by a recent discovery of the significance of DNMT3A-destabilizing mutations (DNMT3AINS) in AML, we here investigate the common characteristics of DNMT3AINS AML methylomes through computational analyses. We present that...

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PMID: 39794314
DOI: 10.1038/s41467-024-55691-z

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