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Article

Landscape of biallelic DNMT3A mutant myeloid neoplasms.

Journal of hematology & oncology - 27 Sept 2024

Kawashima Naomi, Kubota Yasuo, Bravo-Perez Carlos, Guarnera Luca, Williams Nakisha D, Durmaz Arda, Witt Michaela, Ahmed Arooj, Gurnari Carmelo, Maciejewski Jaroslaw P, Visconte Valeria

Abstract excerpt

DNA methyltransferase 3 A mutations (DNMT3AMT) are frequent in myeloid neoplasia (MN) and mostly heterozygous. However, cases with multiple DNMT3AMT can be also encountered but their clinical and genetic landscape remains unexplored. We retrospectively analyzed 533 cases with DNMT3AMT identified out of 5,603 consecutive MNs, of whom 8.4% had multiple DNMT3AMT hits. They were most frequent in acute myeloid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39334207
DOI: 10.1186/s13045-024-01607-9
PMCID: PMC11438130

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