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Article

Epimutations mimic genomic mutations of DNMT3A in acute myeloid leukemia.

Leukemia - 1 Jun 2014

Jost E, Lin Q, Weidner C I, Wilop S, Hoffmann M, Walenda T, Schemionek M, Herrmann O, Zenke M, Brümmendorf T H, Koschmieder S, Wagner W

Abstract excerpt

Mutations in the genetic sequence of the DNA de novo methyltransferase DNMT3A (DNA methyltransferase 3A) are found in many patients with acute myeloid leukemia (AML). They lead to dysfunction of DNMT3A protein and represent a marker for poor prognosis. Effects of genetic mutations can be mimicked by epigenetic modifications in the DNA methylation (DNAm) pattern. Using DNAm profiles of the Cancer Genome Atlas...

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Share to DNA (Cytosine-5-)-Methyltransferases
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methyltransferase 3A

Share to Epigenesis, Genetic

Share to Leukemia, Myeloid, Acute

Share to Oligonucleotide Array Sequence Analysis

Share to Real-Time Polymerase Chain Reaction

Share to Survival Rate

Source

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Identifiers

PMID: 24280869
DOI: 10.1038/leu.2013.362
PMCID: PMC4051212

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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