Article

<i>Trans</i>-eQTL mapping prioritises<i>USP18</i>as a negative regulator of interferon response at a lupus risk locus

2024-07-16

Abstract excerpt

Although genome-wide association studies have provided valuable insights into the genetic basis of complex traits and diseases, translating these findings to causal genes and their downstream mechanisms remains challenging. We performed trans expression quantitative trait locus ( trans -eQTL) meta-analysis in 3,734 lymphoblastoid cell line samples, identifying four robust loci that replicated in an independent mul...

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Literature Corpus work: dd518fda-36d2-58b6-b892-cc0bceaa2785
DOI: 10.1101/2024.07.15.24310442

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