Article

Human USP18 is regulated by miRNAs <i>via</i> the 3’UTR, a sequence duplicated in lincRNA genes residing in chr22q11.21

2020-10-08

Abstract excerpt

<h4>ABSTRACT</h4> Ubiquitin-specific peptidase 18 (USP18) acts as gatekeeper of type I interferon (IFN) responses by binding to the IFN receptor subunit IFNAR2 and preventing activation of the downstream JAK/STAT pathway. In any given cell type, the level of USP18 is a key determinant of the output of interferon-stimulated transcripts. How the baseline level of USP18 is finely tuned in different cell types remain...

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Literature Corpus work: 132aa509-f1f4-5df7-a336-c8b179aa6066
DOI: 10.1101/2020.10.07.328385

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