Article

<i>Parp1</i> deletion rescues cerebellar hypotrophy in <i>xrcc1</i> mutant zebrafish

2024-11-25

Abstract excerpt

Defects in DNA single-strand break repair are associated with neurodevelopmental and neurodegenerative disorders. One such disorder is that resulting from mutations in XRCC1 , a scaffold protein that plays a central role in DNA single-strand base repair. XRCC1 is recruited at sites of single-strand breaks by PARP1, a protein that detects and is activated by such breaks and is negatively regulated by XRCC1 to prev...

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Literature Corpus work: dd515358-3d09-5676-8e49-037ab9591590
DOI: 10.1101/2024.11.25.625242

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