Article

Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in <i>PARP1</i> causing PARP inhibitor resistance

2017-10-14

Abstract excerpt

PARP inhibitors (PARPi) target homologous recombination defective tumour cells via synthetic lethality. Genome-wide and high-density CRISPR-Cas9 “tag, mutate and enrich” mutagenesis screens identified single amino acid mutations in PARP1 that cause profound PARPi-resistance. These included PARP1 mutations outside of the DNA interacting regions of the protein, such as mutations in solvent exposed regions of the cat...

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Identifiers and source

Literature Corpus work: 7669a21c-7af7-5997-ad2d-1c1aff0d1244
DOI: 10.1101/203224

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