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PARP inhibition impedes the maturation of nascent DNA strands during DNA replication

24 Mar 2022

Abstract excerpt

Abstract Poly(ADP-ribose) polymerase 1 (PARP1) is implicated in the detection and processing of unligated Okazaki fragments and other DNA replication intermediates, highlighting such structures as potential sources of genome breakage induced by PARP inhibition. Here, we show that PARP1 activity is greatly elevated in chicken and human S phase cells in which FEN1 nuclease is genetically deleted and is highest...

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PMID: 35332322
DOI: 10.1038/s41594-022-00747-1

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