Article

A novel crosstalk between Nrf2 and Smad2/3 bridged by two nuanced Keap1 isoforms

2022-11-23

Abstract excerpt

The Keap1-Nrf2 signalling to transcriptionally regulate antioxidant response element (ARE)-driven target genes has been accepted as key redox-sensitive pathway governing a vast variety of cellular stresses during healthy survival and disease development. Herein, we identified two nuanced isoforms α and β of Keap1, arising from its first and another in-frame translation starting codons, respectively. In identifying...

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Literature Corpus work: dd40d1a7-bcb8-5478-896a-3a6ab6d02319
DOI: 10.1101/2022.11.22.517594

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