Article

Directed differentiation of hPSCs through lateral plate mesoderm for generation of articular cartilage progenitors

2021-03-24

Abstract excerpt

Developmentally the articular joints are derived from lateral plate (LP) mesoderm. However, no study has produced LP derived prechondrocytes or preosteoblasts from human pluripotent stem cells (hPSC) in a chemically defined manner. Differentiation of hPSCs through the authentic route, via an LP-osteochondral progenitor (OCP), may aid understanding of human cartilage development and the generation of effective cell...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 42bb1575-44f7-549d-bb45-94693ea7f0e6
DOI: 10.1101/2021.03.24.436807

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Directed differentiation of hPSCs through lateral plate mesoderm for generation of articular cartilage progenitorsDOI 10.1101/2021.03.24.436807Read

Directed differentiation of hPSCs through a simplified lateral plate mesoderm protocol for generation of articular cartilage progenitorsSemantic proximity Read

Differentiation of human induced pluripotent stem cells into nucleus pulposus-like cellsSemantic proximity Read

Development of pluripotent stem cell‐based human tenocytesSemantic proximity Read

Human chondrogenic paraxial mesoderm, directed specification and prospective isolation from pluripotent stem cellsSemantic proximity Read

Comparison of Four Protocols to Generate Chondrocyte-Like Cells from Human Induced Pluripotent Stem Cells (hiPSCs)Semantic proximity Read

Directed Differentiation of Notochord-like and Nucleus Pulposus-like Cells Using Human Pluripotent Stem CellsSemantic proximity Read

Lateral Mesoderm-Derived Mesenchymal Stem Cells With Robust Osteochondrogenic Potential and Hematopoiesis-Supporting AbilitySemantic proximity Read

Generating Cartilage Repair from Pluripotent Stem CellsSemantic proximity Read

Engineering Musculoskeletal Tissues with Human Embryonic Germ Cell DerivativesSemantic proximity Read

Modeling human limb skeletal development using human pluripotent stem cell-derived skeletal assembloidsSemantic proximity Read

Recapitulation of endochondral ossification by hPSC-derived SOX9+ sclerotomal progenitorsSemantic proximity Read

Derivation of Isogenic Mesodermal and Ectomesodermal Chondrocytes from Human Induced Pluripotent Stem Cells for Articular Cartilage RegenerationSemantic proximity Read