Article

Single-Cell Sequencing Unravels Heterogeneity in Annulus Fibrosus Cells and Highlights PRG4 as a Potential Marker in Disc Degeneration

2023-10-28

Abstract excerpt

<h4>Background: </h4> Intervertebral disc degeneration is characterized by the rupture of annulus fibrosus (AF) structures, precipitating nucleus pulposus herniation. Ensuring robust AF healing is pivotal for optimal disc repair. Incomplete or delayed AF healing can culminate in recurrent herniations following surgical interventions. While the reactive nature of the AF to degeneration is acknowledged, the molecula...

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Literature Corpus work: 8636ae37-99a6-5905-bdb7-a84f021e55ef
DOI: 10.21203/rs.3.rs-3484013/v1

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