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Article

RSPO2 defines a distinct undifferentiated progenitor in the tendon/ligament and suppresses ectopic ossification

19 Aug 2022

Abstract excerpt

Ectopic endochondral ossification in the tendon/ligament is caused by repetitive mechanical overload or inflammation. Tendon stem/progenitor cells (TSPCs) contribute to tissue repair, and some express lubricin [proteoglycan 4 (PRG4)]. However, the mechanisms of ectopic ossification and association of TSPCs are not yet known. Here, we investigated the characteristics of Prg4-positive ( + ) cells and identified...

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PMID: 35984875
DOI: 10.1126/sciadv.abn2138

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