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Article

A GPVI-platelet-neutrophil-NET axis drives systemic sclerosis

2025-01-24

Abstract excerpt

<h4>ABSTRACT</h4> Systemic sclerosis (SSc) is immune-mediate inflammatory disease characterized by progressive tissue fibrosis. We observed that circulating neutrophils from patients with diffuse SSc exhibit an activated phenotype, a finding echoed in blood and skin transcriptomes. Neutrophil depletion abrogated experimental SSc induced by cutaneous injection of hypochlorous acid (HOCl) or bleomycin (BLM), and ad...

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Identifiers and source

Literature Corpus work
dd266cf5-87db-519a-8fcc-e1ee92f6dfd2
DOI
10.1101/2025.01.21.634123
Open publication

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A GPVI-platelet-neutrophil-NET axis drives systemic sclerosisDOI 10.1101/2025.01.21.634123
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