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Epigenomics of Idiopathic Pulmonary Fibrosis: Evaluating the First Steps

1 Sept 2012

Abstract excerpt

In this study, using sLC and CD11b-DTR techniques, monocytes were depleted from both peripheral blood by 70-95% and spleen by 50-70%.Administration of MC21 mAb removed 45% of the PBMs.Whether or not the three techniques have an influence on monocytes and neutrophils in the bone marrow was not reported.It is crucial to cautiously choose depletion strategies because monocytes are able to migrate among different...

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PMID: 22984022
DOI: 10.1164/rccm.201208-1350ed

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