Defining the neutrophil phenotype in systemic sclerosis

Abstract excerpt

Background: Systemic sclerosis (SSc) is a disease characterised by a triad of immunological abnormalities, endothelial cell dysfunction and fibrosis. Neutrophils are the most abundant circulating leukocyte. They contain several mediators which when released can lead to modulation of the inflammatory response, cause endothelial cell activation and injury and eventually lead to fibrosis. The peri-endothelial cell en...

Topics

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• Antigens, CD
• Biomarkers
• Fibrosis
• Immunity, Innate
• Neutrophils
• Phenotype
• Pulmonary Fibrosis
• Scleroderma, Systemic

Identifiers and source

Literature Corpus work

65f24150-8b1b-51f5-a857-927afd086395

DOI

10.17638/00001414