Article

Transcriptional activation of Jun and Fos members of the AP-1 complex is a conserved signature of immune aging that contributes to inflammaging

2022-08-15

Abstract excerpt

<h4>ABSTRACT</h4> Diverse mouse strains have different health and life spans, mimicking the diversity among humans. To capture conserved aging signatures, we studied long-lived C57BL/6J and short-lived NZO/HILtJ mouse strains by profiling transcriptomes and epigenomes of immune cells from peripheral blood and the spleen from young and old mice. Transcriptional activation of the AP-1 transcription factor complex,...

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Literature Corpus work: cd56d0cf-47e8-5afd-936f-d648f48a7c0f
DOI: 10.1101/2022.08.15.503978

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Transcriptional activation of Jun and Fos members of the AP-1 complex is a conserved signature of immune aging that contributes to inflammagingDOI 10.1101/2022.08.15.503978Read

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