Article

Comprehensive single cell aging atlas of mammary tissues reveals shared epigenomic and transcriptomic signatures of aging and cancer

2023-10-23

Abstract excerpt

Aging is the greatest risk factor for breast cancer; however, how age-related cellular and molecular events impact cancer initiation is unknown. We investigate how aging rewires transcriptomic and epigenomic programs of mouse mammary glands at single cell resolution, yielding a comprehensive resource for aging and cancer biology. Aged epithelial cells exhibit epigenetic and transcriptional changes in metabolic, pr...

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Literature Corpus work: c19ebe18-eeca-5dca-bab3-8f2c5bc2e3f5
DOI: 10.1101/2023.10.20.563147

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