Article

Fibroblast growth factor-21 induces skeletal muscle atrophy and increases plasma amino acids in female mice: a potential role for glucocorticoids

2023-07-03

Abstract excerpt

<h4>Background</h4> Fibroblast growth factor-21 (FGF21) is an intercellular signaling molecule secreted by metabolic organs, including skeletal muscle, in response to intracellular stress. FGF21 crosses the blood brain barrier and acts via the nervous system to coordinate aspects of the adaptive starvation response, including increased lipolysis, gluconeogenesis, hepatic fatty acid oxidation, and activation of th...

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Literature Corpus work: dceee404-4e92-571e-9c96-d861acbf01b0
DOI: 10.1101/2023.06.27.546599

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