Article

Sex-specific metabolic responses to modulation of the glucagon-FGF21 axis in female mice

2025-04-15

Abstract excerpt

Fibroblast growth factor 21 (FGF21) and glucagon are key regulators of energy homeostasis. However, male-biased preclinical studies overlook critical sex differences in metabolism, hindering our understanding of FGF21’s role in glucagon’s effects on females and effective treatments for women with metabolic diseases. We investigated the physiological effects of FGF21 deficiency in female mice fed a chow or obesogen...

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Literature Corpus work: 8e3fbb67-3fef-5c6e-b011-f8e13dc5b91e
DOI: 10.1101/2025.04.09.647697

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