Article
Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework.
Cell metabolism - 11 Oct 2016
Solon-Biet Samantha M, Cogger Victoria C, Pulpitel Tamara, Heblinski Marika, Wahl Devin, McMahon Aisling C, Warren Alessandra, Durrant-Whyte Jessica, Walters Kirsty A, Krycer James R, Ponton Fleur, Gokarn Rahul, Wali Jibran A, Ruohonen Kari, Conigrave Arthur D, James David E, Raubenheimer David, Morrison Christopher D, Le Couteur David G, Simpson Stephen J
Abstract excerpt
Fibroblast growth factor 21 (FGF21) is the first known endocrine signal activated by protein restriction. Although FGF21 is robustly elevated in low-protein environments, increased FGF21 is also seen in various other contexts such as fasting, overfeeding, ketogenic diets, and high-carbohydrate diets, leaving its nutritional context and physiological role unresolved and controversial. Here, we use the Geometric...
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