Article
Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21.
Science signaling - 10 Nov 2015
Guridi Maitea, Tintignac Lionel A, Lin Shuo, Kupr Barbara, Castets Perrine, Rüegg Markus A
Abstract excerpt
Skeletal muscle is the largest organ, comprising 40% of the total body lean mass, and affects whole-body metabolism in multiple ways. We investigated the signaling pathways involved in this process using TSCmKO mice, which have a skeletal muscle-specific depletion of TSC1 (tuberous sclerosis complex 1). This deficiency results in the constitutive activation of mammalian target of rapamycin complex 1 (mTORC1),...
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