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Spaceflight induces changes in gene expression profiles linked to insulin and estrogen

11 Jun 2024

Abstract excerpt

Organismal adaptations to spaceflight have been characterized at the molecular level in model organisms, including Drosophila and C. elegans. Here, we extend molecular work to energy metabolism and sex hormone signaling in mice and humans. We found spaceflight induced changes in insulin and estrogen signaling in rodents and humans. Murine changes were most prominent in the liver, where we observed inhibition of...

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PMID: 38862620
DOI: 10.1038/s42003-023-05213-2

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