Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21.

Aging cell - 1 Oct 2014

Lees Emma K, Król Elżbieta, Grant Louise, Shearer Kirsty, Wyse Cathy, Moncur Eleanor, Bykowska Aleksandra S, Mody Nimesh, Gettys Thomas W, Delibegovic Mirela

Abstract excerpt

Methionine restriction (MR) decreases body weight and adiposity and improves glucose homeostasis in rodents. Similar to caloric restriction, MR extends lifespan, but is accompanied by increased food intake and energy expenditure. Most studies have examined MR in young animals; therefore, the aim of this study was to investigate the ability of MR to reverse age-induced obesity and insulin resistance in adult...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Energy Metabolism
Share to Fibroblast Growth Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression

Share to Glucose

Share to Insulin Resistance

Share to Lipid Metabolism

Share to Methionine

Share to Obesity

Source

Open in PubMed Open full text

Identifiers

PMID: 24935677
DOI: 10.1111/acel.12238
PMCID: PMC4331744

Genes

FGF21
ATF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21.PMID 24935677Read ↗

Metabolic adaptations to methionine restriction that benefit health and lifespan in rodents.Semantic proximity Read ↗

Short‐term methionine deprivation improves metabolic health via sexually dimorphic, mTORCI‐independent mechanismsSemantic proximity Read ↗

Physiological and Molecular Mechanisms of Methionine RestrictionSemantic proximity Read ↗

Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to miceSemantic proximity Read ↗

Calorie restriction and life-extending mutation downregulate miR-34a to facilitate lipid metabolism in the liver.Semantic proximity Read ↗

Protein Restriction in Metabolic Health: Lessons from Rodent ModelsSemantic proximity Read ↗

Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21.Semantic proximity Read ↗

Fibroblast growth factor-21 induces skeletal muscle atrophy and increases plasma amino acids in female mice: a potential role for glucocorticoidsSemantic proximity Read ↗

Protein restriction, epigenetic diet, intermittent fasting as new approaches for preventing age-associated diseasesSemantic proximity Read ↗

Calorie restriction as an intervention in ageingSemantic proximity Read ↗

A systems biology analysis of the unique and overlapping transcriptional responses to caloric restriction and dietary methionine restriction in ratsSemantic proximity Read ↗

Short-term Ketogenic Diet Induces a Molecular Response that is Distinct from Dietary Protein RestrictionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.