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Article

Memory-like HCV-specific CD8+ T cells retain a molecular scar after cure of chronic HCV infection.

Nature immunology - 1 Feb 2021

Hensel Nina, Gu Zuguang, Sagar, Wieland Dominik, Jechow Katharina, Kemming Janine, Llewellyn-Lacey Sian, Gostick Emma, Sogukpinar Oezlem, Emmerich Florian, Price David A, Bengsch Bertram, Boettler Tobias, Neumann-Haefelin Christoph, Eils Roland, Conrad Christian, Bartenschlager Ralf, Grün Dominic, Ishaque Naveed, Thimme Robert, Hofmann Maike

Abstract excerpt

In chronic hepatitis C virus (HCV) infection, exhausted HCV-specific CD8+ T cells comprise memory-like and terminally exhausted subsets. However, little is known about the molecular profile and fate of these two subsets after the elimination of chronic antigen stimulation by direct-acting antiviral (DAA) therapy. Here, we report a progenitor-progeny relationship between memory-like and terminally exhausted...

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Share to Antigens, Viral
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 33398179
DOI: 10.1038/s41590-020-00817-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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