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Article

Single-cell multimodal analysis reveals the dynamic immunopathogenesis of HBV-ACLF progression

21 Aug 2025

Abstract excerpt

Background Acute-on-chronic liver failure (ACLF) is a life-threatening syndrome involving dysfunction of multiple immune cell types. Objective This study aimed to comprehensively depict the dynamic trajectory of immune responses throughout the disease course of HBV-related ACLF (HBV-ACLF). Design Single-cell RNA sequencing and single-cell proteomics were performed on the peripheral blood mononuclear cells of 45...

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PMID: 40841166
DOI: 10.1136/gutjnl-2024-333308

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