Article

An Atlas of Immune Cell Exhaustion in HIV-Infected Individuals Revealed by Single-Cell Transcriptomics

2019-06-21

Abstract excerpt

Chronic infection with human immunodeficiency virus (HIV) can cause progressive loss of immune cell function, or exhaustion, which impairs control of virus replication. However, little is known about the development and maintenance, as well as heterogeneity of immune cell exhaustion. Here, we investigated the effects of HIV infection on immune cell exhaustion at the transcriptomic level by analyzing single-cell RN...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3f487d84-2e92-5128-82f3-1cd113632f6e
DOI: 10.1101/678763

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An Atlas of Immune Cell Exhaustion in HIV-Infected Individuals Revealed by Single-Cell TranscriptomicsDOI 10.1101/678763Read

Global transcriptomic characterization of T cells in individuals with chronic HIV-1 infectionSemantic proximity Read

Identification of human progenitors of exhausted CD8+ T cells associated with elevated IFN-γ response in early phase of viral infectionSemantic proximity Read

Single cell multi-omics reveals early elevated function and multiple fates within human progenitor exhausted CD8 <sup>+</sup> T cellsSemantic proximity Read

Transcriptomic crosstalk between viral and host factors drives aberrant homeostasis of T-cell proliferation and cell death in HIV-infected immunological non-respondersSemantic proximity Read

CD4highCD8low double-positive T cells with high differentiation mediate incomplete immune reconstitution in HIV-infected patientsSemantic proximity Read

Decoding Immune Reconstitution Failure in People Living with HIV through Single-cell GenomicsSemantic proximity Read

Multi-Omics Single-Cell Analysis Reveals Key Regulators of HIV-1 Persistence and Aberrant Host Immune Responses in Early InfectionSemantic proximity Read

Comprehensive phenotyping of circulating immune cell subsets in people living with HIVSemantic proximity Read

Gene dysregulation in acute HIV-1 infection – early transcriptomic analysis reveals the crucial biological functions affectedSemantic proximity Read

Omic Technologies in HIV: Searching Transcriptional Signatures Involved in Long-Term Non-Progressor and HIV Controller Phenotypes.Semantic proximity Read

Gene dysregulation among virally suppressed people living with HIV links to non-AIDS defining cancer pathwaysSemantic proximity Read

Molecular signature of CD8+ T cell exhaustion during chronic viral infection.Semantic proximity Read