Article

Unveiling the Immune Landscape of COVID-19 and prolonged Long-COVID through Single-Cell RNA Sequencing

2025-03-11

Abstract excerpt

Long-COVID affects at least 10% of COVID-19 survivors, displaying debilitating symptoms across multiple organ systems. Despite the increasing prevalence, the underlying causes remain unclear. This study presents a unique analysis of the PBMC transcriptomic landscape of COVID-19 and Long-COVID patients at a single-cell resolution. We reconstructed the cell state and communication using differentially expressed gene...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 01e0cec3-05fc-5ba5-8362-35cedf53d4b2
DOI: 10.1101/2025.03.05.641671

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Unveiling the Immune Landscape of COVID-19 and prolonged Long-COVID through Single-Cell RNA SequencingDOI 10.1101/2025.03.05.641671Read

Single-Cell Omics Reveals Dyssynchrony of the Innate and Adaptive Immune System in Progressive COVID-19Semantic proximity Read

Single-cell profiling of innate and adaptive immune dysregulation in Long COVIDSemantic proximity Read

Single-cell multiomics revealed the dynamics of antigen presentation, immune response and T cell activation in the COVID-19 positive and recovered individualsSemantic proximity Read

Cell specific peripheral immune responses predict survival in critical COVID-19 patientsSemantic proximity Read

Identification of Distinct Immune Cells Associated with Various Clinical Presentations of COVID-19Semantic proximity Read

A single-cell atlas of lymphocyte adaptive immune repertoires and transcriptomes reveals age-related differences in convalescent COVID-19 patientsSemantic proximity Read

A Single-Cell Atlas of Lymphocyte Adaptive Immune Repertoires and Transcriptomes Reveals Age-Related Differences in Convalescent COVID-19 PatientsSemantic proximity Read

Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencingSemantic proximity Read

People critically ill with COVID-19 exhibit peripheral immune profiles predictive of mortality and reflective of SARS-CoV-2 lung viral burdenSemantic proximity Read

Characterisation of the blood RNA host response underpinning severity in COVID-19 patientsSemantic proximity Read

Large-scale single-cell analysis reveals critical immune characteristics of COVID-19 patientsSemantic proximity Read

Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection TrajectoriesSemantic proximity Read