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Article

Early Transcriptional Divergence Marks Virus-Specific Primary Human CD8+ T Cells in Chronic versus Acute Infection.

Immunity - 17 Oct 2017

Wolski David, Foote Peter K, Chen Diana Y, Lewis-Ximenez Lia L, Fauvelle Catherine, Aneja Jasneet, Walker Andreas, Tonnerre Pierre, Torres-Cornejo Almudena, Kvistad Daniel, Imam Sabrina, Waring Michael T, Tully Damien C, Allen Todd M, Chung Raymond T, Timm Jörg, Haining W Nicholas, Kim Arthur Y, Baumert Thomas F, Lauer Georg M

Abstract excerpt

Distinct molecular pathways govern the differentiation of CD8+ effector T cells into memory or exhausted T cells during acute and chronic viral infection, but these are not well studied in humans. Here, we employed an integrative systems immunology approach to identify transcriptional commonalities and differences between virus-specific CD8+ T cells from patients with persistent and spontaneously resolving...

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Identifiers

PMID: 29045899
DOI: 10.1016/j.immuni.2017.09.006
PMCID: PMC5708133

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