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Article

The Path to Cancer --Three Strikes and You're Out.

The New England journal of medicine - 12 Nov 2015

Vogelstein Bert, Kinzler Kenneth W

Abstract excerpt

Focusing on driver-gene mutations and the pathways they control has rendered complex cancer-genome landscapes intelligible. In solid tumors of adults, alterations in as few as three driver genes appear to suffice for a cell to evolve into an advanced cancer.

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Share to Cancer Genomics and Diagnostics
Share to Cell Transformation, Neoplastic
Share to Lung Cancer Treatments and Mutations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26559569
DOI: 10.1056/NEJMp1508811

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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