Article

A First-principles Approach to Large-scale Nuclear Architecture

2018-05-07

Abstract excerpt

Model approaches to nuclear architecture have traditionally ignored the biophysical consequences of ATP-fueled active processes acting on chromatin. However, transcription-coupled activity is a source of stochastic forces that are substantially larger than the Brownian forces present at physiological temperatures. Here, we describe a first-principles approach to large-scale nuclear architecture in metazoans that i...

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Literature Corpus work: dcc44531-cdbd-5622-9d03-9f524dde8b11
DOI: 10.1101/315812

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