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Revealing potential drug targets in schizophrenia through proteome-wide Mendelian randomization genetic insights.

Progress in neuro-psychopharmacology & biological psychiatry - 10 Jan 2025

Xie Wenhuo, Zheng Jiaping, Kong Chenghua, Luo Wei, Lin Xiaoxia, Zhou Yu

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BACKGROUND: Schizophrenia (SCZ) is a severe, chronic mental disorder with no current cure. Identifying novel pharmacological targets is crucial for developing more effective treatments. METHODS: We performed two-sample Mendelian randomization (MR) analyses to estimate the associations between cerebrospinal fluid (CSF) containing 154 proteins and plasma containing 734 proteins and risk of SCZ. Bidirectional MR...

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Bayes Theorem
Genetic Predisposition to Disease
Genome-Wide Association Study
Mendelian Randomization Analysis
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PMID: 39615872
DOI: 10.1016/j.pnpbp.2024.111208

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