A frontotemporal dementia-like phenotype in schizophrenia: links to striatal dopamine and iron accumulation.

doi:10.1038/s41386-026-02426-x

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Article

A frontotemporal dementia-like phenotype in schizophrenia: links to striatal dopamine and iron accumulation.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Oct 2026

Chang Xuanhan, Bryant Linda, Mena Ortega Sergio, Howes Oliver, Sedlacik Jan, Veronese Mattia, Schroeter Matthias L, Lalousis Paris Alexandros, Koutsouleris Nikolaos, Vano Luke, Coutts Fiona

Abstract excerpt

Some schizophrenia patients share characteristics with behavioral variant frontotemporal dementia (bvFTD) including gray matter volume (GMV) similarities, suggesting overlapping brain mechanisms that may contribute to disease heterogeneity in schizophrenia. However, it is not yet understood whether schizophrenia patients with a bvFTD-like GMV signature also show additional features of bvFTD. Seventy-six patients...

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Topics

Adult
Female
Humans
Male
Middle Aged
Young Adult

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Corpus Striatum

Dihydroxyphenylalanine

Dopamine

Dopaminergic Imaging

Frontotemporal Dementia

Gray Matter

Iron

Magnetic Resonance Imaging

Phenotype

Positron-Emission Tomography

Schizophrenia

Clinical Trials, Phase I as Topic

Source

Open in PubMed Open full text

Identifiers

PMID: 42034849
DOI: 10.1038/s41386-026-02426-x
PMCID: PMC13598093

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