Article

Gene-diet interaction analysis in UK Biobank identified genetic loci that modify the association between fish oil supplementation and the incidence of dementia

2024-11-10

Abstract excerpt

<h4>Background</h4> Dementia is a common disease influenced by both genetic and environmental factors. APOE ε4 is well-known to increase the risk of dementia, and it has been shown to attenuate the protective association of fish oil supplementation and the incidence of dementia. To identify more genetic factors with similar modifying effects, we performed a genome-wide scan. <h4>Methods</h4> We first performed tim...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dcadf0c3-1ccd-586f-87f9-d45f97cb7ed0
DOI: 10.1101/2024.11.08.24316999

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gene-diet interaction analysis in UK Biobank identified genetic loci that modify the association between fish oil supplementation and the incidence of dementiaDOI 10.1101/2024.11.08.24316999Read

Use of fish oil supplements is differently related to incidence of all-cause and vascular dementia among people with the distinct APOE ε4 dosage.Semantic proximity Read

Lipid associated polygenic enrichment in Alzheimer’s diseaseSemantic proximity Read

Higher plasma omega-6 fatty acids are associated with lower dementia risk: evidence from NMR metabolomics and Alzheimer's disease polygenic risk in the UK Biobank.Semantic proximity Read

Blood and Brain Transcriptome Analysis Reveals APOE Genotype-mediated and Immune-related Pathways Involved in Alzheimer DiseaseSemantic proximity Read

Polyunsaturated fatty acids, APOE genotypes, and dementia incidence and mortality among hypertensive adultsSemantic proximity Read

Interactions between dietary patterns and genetic factors in relation to incident dementia among 70-year-olds.Semantic proximity Read

A multivariable Mendelian randomisation study of serum lipids and dementia risk within the UK BiobankSemantic proximity Read

Benefits of fatty fish on dementia risk are stronger for those without APOE epsilon4.Semantic proximity Read

Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population.Semantic proximity Read

Causal insights of modifiable cardiovascular risk factors for dementia risk - potential for efficient prevention and improved brain health.Semantic proximity Read

APOE Genotype Modulates the Relationship of Stroke With Dementia Risk: Associations and Peripheral Clues for Biological Mechanisms.Semantic proximity Read

Interaction between genetic predisposition, smoking, and dementia risk: a population-based cohort study.Semantic proximity Read