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Higher plasma omega-6 fatty acids are associated with lower dementia risk: evidence from NMR metabolomics and Alzheimer's disease polygenic risk in the UK Biobank.

Frontiers in public health - 1 Jan 2026

Luo Li, Gong Siyin, Liu Dan, Zhou Kunyan

Abstract excerpt

Background: Circulating polyunsaturated fatty acids (PUFAs) have been implicated in neurodegenerative processes, yet epidemiological evidence remains inconsistent. Genetic susceptibility to Alzheimer's disease (AD), commonly indexed by a polygenic risk score (PRS), is a major determinant of dementia risk. However, few large-scale prospective studies have jointly examined plasma fatty acid profiles and genetic...

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Identifiers

PMID: 42221673
DOI: 10.3389/fpubh.2026.1816467
PMCID: PMC13216053

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